SepFastTM Macro IEX Media
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Specially designed for the purification of large and complex protein molecules such as pegylated drug materials, SepFast Macro Q and SepFast Macro S is a group of strong anion exchange and strong cation exchange chromatography media, respectively.
The base matrix is made of highly cross-linked polysaccharides. It is very stable to most of the chemical conditions experienced in the bioprocessing industry. We provide the regulatory support files of individual resins for those cGMP applications.
The core advantages to large-scale biomanufacturing are:
- Improved binding capacity
- Good pressure / flow property
- High Resolution
Characteristics of SepFast Macro products
|SepFast Macro Q||SepFast Macro S|
|Matrix||Highly cross-linked polysaccharides|
|Functionalgroup||Quaternary ammonium strong anion||Sulfo strong cation|
|Total ionic capacity||0.08-0.16 mmol/ml||0.08-0.16 mmol/ml|
|Particle size||20 – 50 μm|
|Pressure-flow property*||>100 cm/h|
|Operational pressure||Up to 6 bar|
|pH stability||2-14 (short term) and 3-12 (long term)|
|Working temperature||4oC – 30oC|
|Chemical stability||All commonly used buffers; 1 M acetic acid, 1 M NaOH, 6M guanidine hydrochloride, 8 M urea, 30% isopropanol, 70% ethanol|
|Total ionic capacity||Oxidizing agents, anionic detergents or cationic detergents|
|Storage||20% ethanol||20% ethanol + 0.2 M sodium acetate|
*Measured in a 32 mm ID column at a bed height of 15 cm.
|Description||Quantity||Code no.||Price GBP|
|SepFast Macro Q||25 ml||460101||£89.25|
|SepFast Macro S||25 ml||460201||£89.25|
*Pre-packed process development columns are available on request..